Free online dating and matchmaking service for singles. Start Dating Now... Stay Online - Online FM - SMS - Online Games - Dating Advice - Find Friends
Dating Funda - Free Online Dating in India, USA, UK, Australia,   Click here for more.
Dating Funda HomeDating PeoplesDating PhotosDating VideosDating Clubs Register For DatingMy Dating AccountLogin For Date
Members Members [5]
Topics Topics [12]
Manage Club Manage Club

Home > Clubs > Science and History > Science & Technology > Topics > Study points to why stress may affect women more

Study points to why stress may affect women more

Post Reply

saki[2]
Posted on : 19 Jun 2010 04:37 pm
Study points to why stress may affect women more

There may be a bi­o­log­i­cal rea­son why more wom­en than men suf­fer stress-related psy­chi­at­ric dis­or­ders, a study sug­gests.

Stud­y­ing stress sig­nal­ing mo­le­cules in rat brains, re­search­ers found that fe­males are more sen­si­tive than males to low lev­els of a ma­jor stress hor­mone, and less able to adapt to high lev­els of it.

“This is the first ev­i­dence for sex dif­fer­ences” in this sig­nal­ing sys­tem, said study lead­er Rita J. Val­en­ti­no, a be­hav­ior­al neu­ro­sci­ent­ist at The Chil­dren’s Hos­pi­tal of Phil­a­del­phia. Her re­search ap­peared on­line June 15 in the re­search jour­nal Mo­lec­u­lar Psy­chi­a­try.

The gen­der dif­fer­ences, she ex­plained, in­volve the way mo­lec­u­lar struc­tures on brain cell sur­faces, called re­cep­tors, han­dle the traf­fic of stress sig­nal­ing molecules. “Although more re­search is cer­tainly nec­es­sary to de­ter­mine wheth­er this trans­lates to hu­mans, this may help to ex­plain why wom­en are twice as vulnera­ble as men to stress-related dis­or­ders,” she added.

Wom­en have a high­er in­ci­dence of de­pres­sion, post-traumatic stress dis­or­der, and oth­er anx­i­e­ty dis­or­ders, said Val­en­ti­no.

Her re­search fo­cus­es on corticotropin-releasing fac­tor, or CRF, a hor­mone that or­ga­nizes stress re­sponses in mam­mals. An­a­lyz­ing the brains of rats put through a swim stress test, Val­en­ti­no’s team found that in fe­male rats, brain cells had re­cep­tors for CRF that at­tached more tightly to cell sig­nal­ing pro­teins than in male rats. The re­cep­tors thus re­sponded more strongly to the stress hor­mone.

Fur­ther­more, Val­en­ti­no said, stressed male rats dis­played an adaptive re­sponse, called in­ter­nal­iz­a­tion, in their brain cells. These cells re­duced the num­ber of CRF re­cep­tors, and be­came less re­spon­sive to the hor­mone. In fe­male rats this did­n’t hap­pen be­cause a spe­cif­ic pro­tein did not link up with the CRF re­cep­tor in a way that was needed for this adapta­t­ion, Val­en­ti­no ex­plained.

“We can­not say that the bi­o­log­i­cal mech­an­ism is the same in peo­ple,” she added, not­ing that oth­er mech­an­isms and hor­mones play roles in hu­man stress. But “re­search­ers al­ready know that CRF regula­t­ion is dis­rupted in stress-related psy­chi­at­ric dis­or­ders, so this re­search may be rel­e­vant to the un­der­ly­ing hu­man bi­ol­o­gy.”

 
Post Reply    

 

Account Browse Create Communicate My Stuff Datingfunda

Login
Signup Free

Adult Dating

Dating Peoples
Dating Photos
Dating Clubs
Dating Videos
Dating Articles
Dating Directory
Dating Forum

Profile
Upload Photos
Post Videos
Create Clubs
My OpenSpce
My Messages
Invite Friends
My Profile
My Clubs
My Photos
MY Videos
About
Privacy & Terms of Service
Help

© 2003 - 2011, Datingfunda.com, ALL Rights Reserved.

Powered By Dreamzsop | Rank Monitoring By iizin.com